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Given the current events in Lebanon, Lebanese physicians working there have been in the news extensively lately. Some have chosen to leave in search of a more stable life; some have chosen to stay, and some have chosen not to move back to Lebanon in the first place. We will interview Lebanese physicians working in Lebanon and beyond to get their opinions about the events taking place in Lebanon, the future of medicine in Lebanon, and the role Lebanese physicians play worldwide in their respective fields, and their connections to their home county. We will highlight success stories, stories that were not so successful, and everything in between. Medical students, physicians-in-training, and attending physicians at different points in their careers will be interviewed. We hope you will find this podcast beneficial and exciting!
Episodes
Sunday Jun 29, 2025
Sunday Jun 29, 2025
In this episode, Dr. Hind Rafei dives into the cutting-edge world of CAR-NK cell therapy and its potential to revolutionize cancer treatment. Unlike their T-cell counterparts, CAR-NK cells promise enhanced safety and innate tumor-killing ability. But what if their power could be dialed up even further?
Dr. Rafei discusses her team's groundbreaking discovery of CREM, a transcriptional regulator that shapes CAR-NK function and limits its full therapeutic potential. We explore how modulating CREM—particularly by deleting or suppressing it—can reprogram these cells to become more effective, resilient cancer fighters.
We unpack the science behind the PKA–CREB pathway, CREM-driven epigenetic changes, and how these findings might lead to next-generation immunotherapies and even cancer vaccines. Finally, Dr. Rafei offers insights on clinical translation and the path ahead for CREM-tuned therapies.
Whether you’re a researcher, clinician, or patient advocate, this episode sheds light on one of the most promising frontiers in cellular immunotherapy.
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